Psilomethoxin:4-Hydroxy-5-methoxydimethyltryptamine, also known as 4-HO-5-MeO-DMT or psilomethoxin, is a novel psychedelic drug. It is the 4-hydroxy counterpart of 5-MeO-DMT, or the 5-methoxy counterpart of psilocin.

In 1965 Marc Julia’s group at the Pasteur Institute synthesized psilomethoxin (4-ho-5-meo-dmt) in a 10-step process from ortho-vanillin extracted from the Mexican vanilla orchid. The molecule was never bioassayed nor preserved as a reference sample.

In the early 1990s, German mycologist Jochen Gartz fed DET, DIPT, and DPT to psilocybe cubensis mushroom substrate and created the completely novel compounds 4-ho-DET, 4-ho-DIPT and 4-ho-DPT. He filed patents on this process, which have since expired.

In November of 2021, the Church of the Sacred Synthesis (aka Church of Psilomethoxin) fed 5-meo-dmt to mushrooms in Mexico and tested the resulting sacrament. Since then, the members of the church have shared the sacrament with thousands of people with tens of thousands of doses shared. To date, there are no adverse event reports.

Psilomethoxin is a new and novel sacrament created in mushroom mycelium by sacred synthesis. Phalaris grass derived amino acid metabolites are added to the mushroom substrate producing Psilomethoxin. This sacred synthesis represents a reunion of spirit/nature with science/medicine and further symbolizes a return to our ancient roots (from Psilomethoxin Church).

Initial reports of Psilomethoxin indicate it is remarkably unique. The result is a sacrament that is best described as a “human optimization” molecule.

Psilomethoxin provides an opportunity to explore your human potential connecting you to your higher wisdom and ethereal body, when used with respect and within an introspective and meditative practice.

Psilomethoxin can help you unlock optimal levels of performance, health, and wellbeing. It can promote self growth, adaptation, and transformation, and provide insight on how to shape your own destiny by optimizing your physical, mental, spiritual and emotional capacities.

A Psilomethoxin ceremony includes a focus on intention and meeting this sacred medicine with heart openness and curiosity by providing a safe, comfortable and supportive setting:

My approach to a Psilomethoxin Ceremony includes:

Safety: a setting that is physically safe, secure and private, to minimize the risk of unwanted interruptions or interactions with strangers.

Comfort: comfortable temperature, lighting, and noise levels appropriate for a going into a deep journey.

Nature: nearby a natural setting, forest, desert, mountain or beach to provide a sense of awe, wonder, and connection to the natural world.

Support: shamanic guide and supporters (therapists, psychonauts, energy healers and coaches trained in psychedelic therapies) who provide emotional support, reassurance, and guidance if needed. A group of professionals and spiritual explorers who are non-judgmental, compassionate, and familiar with the psychedelic experience.

Intention: a clear intention or purpose will be the guiding light for your psychedelic experience. For example, your intention can be to explore inner emotions and thoughts, to revisit and heal past trauma, to enhance creativity, to expand your spiritual awareness, to connect to the core of your being.

As part of your work with a psychedelic medicine, it is important to adopt lifestyle practices, habits, and technologies that aim to improve your way of being like regular exercise, healthy diet, meditation, cognitive training, sleep hygiene, biohacking, introspection, shadow work and the use of psychedelic medicines or other supplements.